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In starvation or low-energy states, SIRT1 activation is regulated by AMPK, which increases lifespan by increasing NAD + levels and activating SIRT1 (Zullo et al., 2018)

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Extensive research has been sparked into the potential induction of ferroptosis in tumor treatment, with several clinically approved drugs (e.g., sorafenib and artesunate) demonstrated to effectively induce ferroptosis (122)