naet glutathione avoidance Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Sulfur partitioning from cysteine controls
Description
Cysteine deprivation is linked to ferroptosis, a non-apoptotic form of cell death that involves lipid peroxidation 31
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The combination therapy of Abrine (IDO1 inhibitors) with anti-PD-1 antibody has a beneficial impact on decreasing HCC growth by upregulating CD4 + or CD8 + T cells, inhibiting Treg cells, and blocking the expression of IDO1 and PD-L1
10.1016/j.bbagen.2012.11.020 [DOI] [PubMed] [Google Scholar] Brown C
