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Since vitamin K is critical for the generation of gla residues in clotting factors, as described above, deficiency in this vitamin results in dysfunction in the processes of blood coagulation

Br J Pharmacol 178(5):11821199 Li L, Huang J, Zhao Z, Wen Z, Li K, Ma T, Zhang L, Zheng J, Liang S (2021b) Decreased Spp1 expression in acute myocardial infarction after ischemia and reperfusion injury

Additionally, Akp3/mice with renal failure reduced intestinal inorganic phosphate absorption, leading to an increase in ATP in intestinal epithelial cells

42, 43 Mitochondrial dysfunction can lead to reduced synaptic neurotransmitter release, and neurons that have high firing rates, such as GABAergic interneurons, may be the most adversely affected