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On the other hand, traditional weight loss methods such as diet and exercise can take longer to produce results and may require more time and effort
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Furthermore, metabolic comorbidities such as insulin resistance indirectly enhance urate reabsorption through NHE3-mediated (sodiumhydrogen exchanger 3) tubular alkalinization, creating a mechanistic link between metabolic syndrome and hyperuricemia (Gong et al., 2020
For instance, while cyclic peptides like CyRL-QN15 gain enzymatic resistance through rigid structures [84], tripeptides such as GHK maintain therapeutic potency while being more adaptable and versatile in formulation
