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Polarity modulation allows for adjustments in the HBA/HBD ratio and water content to match specific compound requirements (233)

Although the precise mechanisms underlying KDs effects in PD remain incompletely understood, evidence suggests that the diet can modulate glucose utilization in the brain, neurotransmitter metabolism, insulin signaling, oxidative stress, neuroinflammation, and ion channel activity, particularly potassium channels [20]

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As Th17 cells appear to contribute to nigrostriatal degeneration (206, 207), the beneficial effect of T reg may be due to their ability to inhibit TH17 cells