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Lobaplatin promotes (125)I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2-ATF4-CHOP pathway

Instead, they fall into the titration camp

Therapeutic strategies targeting core UPR pathways and downstream molecules (e.g., CHOP, GRP78) show anti-tumor potential in preclinical studies, and combination therapies (e.g., with immunotherapy or metabolic intervention) can enhance efficacy

The supernatant was dried and added to 5% trichloroacetic acid (TCA) containing 2% 2-mercaptoethanol to reduce the oxidized form of glutathione, and the mixture was used as the deprotenized plasma fraction