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One major factor is oxidative stress
Similarly, hypothalamic glucagon, lipids and AAs sensing also triggers a neuronal relay, through the hepatic vagus, to lower hepatic glucose production [,,,] [Figure 7]

Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ

While it is vital for overall health, overconsumption, especially through high-dose supplements and foods, an excessive intake of this vitamin may have harmful side effects
