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In preclinical research, GHK-Cu has been studied for wound healing and skin remodelling (collagen synthesis, MMP regulation), angiogenesis and tissue repair mechanisms, anti-inflammatory and antioxidant signalling pathways, and nerve regeneration models

Additionally, overexpression of both arginase isoforms reduces L-arginine availability (Li et al., 2001)

doi: 10.1093/glycob/12.4.43R

Important evaluations of biocompatibility, immunogenicity, degradation, and biodistribution in vivo are also provided with a focus on safety in addition to the regulatory impediments to clinical translation
