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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

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562 Evidence from PD patients has identified reduced plasma ghrelin levels in the fasting state, 563,564 as well as an impaired ghrelin response and secretion in the postprandial state