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Currently, GPx3 is considered a new tumor-suppressor gene [23], and its hypermethylation, which is associated with the further down-regulation of GPx3, was observed in patients with Barretts esophagus [54], endometrial adenocarcinoma [55] and prostate cancer [56]

Given expected heterogeneity, random-effects models using restricted maximum likelihood estimation with KnappHartung adjustments were applied, and implemented in RevMan and metafor (R)

This ensures the peptide is produced under strict quality controls

Each approach, whether oral ingestion or injection, presents distinct advantages, and the decision on whether to opt for oral or injectable forms should be guided by the precise objectives and framework of the research