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Therefore, IN-NPY has been explored in preclinical studies using an R6/2 mouse model of HD to further elucidate its role in HD pathology, with 4 week old mice receiving either IN-NPY, IN-NPY Y2 receptor agonist (NPY 1336 ), or saline 5 days a week for a period of 8 weeks

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Waring MJ, Arrowsmith J, Leach AR, Leeson PD, Mandrell S, Owen RM, Pairaudeau G, Pennie WD, Pickett SD, Wang J, Wallace O, Weir A (2015) An analysis of the attrition of drug candidates from four major pharmaceutical companies

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