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The Structural Genomics Consortium is a registered charity (Number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no

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IGF-1 deficiencies are also implicated in the development of neurodegenerative diseases such as AD (Westwood et al., 2014), while excess levels of IGF-1 are associated with aberrant cellular growth (i.e., cancers) (Qian and Huo, 2020)

Generation of cells stably expressing ADH5 and GCLM Cells carrying the ADH5-expressing plasmid pLox-ADH5-FLAG-CT-BSR 3 were selected using 4 g mL 1 Blasticidin (BSR)