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The term nootropic was coined in 1972 by the Romanian psychologist and chemist Corneliu Giurgea, who had synthesized piracetam at the Belgian firm UCB and found that its pharmacology fit none of the known psychotropic categories.1 From the Greek noos (mind) and trepein (to bend), the word described something specific

Its stability in gastric juice and lack of reported toxicity in early inflammatory-bowel-disease clinical work are recurring features of the literature 2

The regular "rubber" of your gut lining is typically in tact, then when exposed to the "heat" (inflammation) for long periods, comes apart and "cracks," which allows particles to "leak" through the barrier and into the bloodstream, where they attract an immune response