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Consequently, downregulation or knockdown of GR in prostate carcinoma cell lines led to the downregulation of LEDGF/p75 expression, reduced clonogenicity and tumoursphere formation as well as enhanced their sensitivity to docetaxel-induced tumour cell death [177]

T cells exert antigen-specific cytotoxicity but are frequently rendered dysfunctional by chronic stimulation and inhibitory cues in the tumour microenvironment, a phenomenon known as T cell exhaustion or anergy that limits antitumour activity (55)

Therefore, understanding the mechanisms underlying the occurrence and development of RF and delaying its progression are highly important

This can allow companies to focus on areas of highest risk as they continually assess and improve their internal procedures and processes
