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In vivo experiments of animals with periodontal defect, IGF-1 coated with gelatin particles was significantly more effective in bone formation than IGF-1 isolated in clot

This may be due to changes in hormones and menopause, which can affect cholesterol rates with the cessation of estrogen production, shifting lipoproteins toward LDL and away from HDL cholesterol in women [180]

It also plays a vital role in red blood cell production and oxygen delivery to tissues

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