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In zebrafish, the colonization of the gut by microorganisms promotes epithelial absorption of fatty acids (Semova et al., 2012) and fish with intact microbiota have increased lipid accumulation in the intestinal epithelium, and increased expression of genes related to lipid metabolism compared to germ-free fish who lack microbiota (Sheng et al., 2018)

Also, mice carrying a genetic mutation that lack one of the igf1r alleles ( igf1r +/ ) show a 10 % reduction in post-natal growth, insulin resistance and glucose intolerance [237]

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia

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