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In OA, elevated ROS production and associated oxidative stress are well-documented, while reduced levels of antioxidant enzymes exacerbate this imbalance, contributing to the pathogenesis of the disease (Chen et al., 2020)

Alternatively, when dietary protein intake is low and blood levels of SAM fall, homocysteine undergoes remethylation to form methionine

When the gut microbiome is imbalanced, estrogen can be reabsorbed rather than eliminated, which can potentially worsen endometriosis symptoms

Conversely, other studies reported no significant differences in GPX3 serum concentrations between obese and lean individuals, although GPX3 expression in subcutaneous adipose tissue increased after weight loss and was greater in lean and insulin-sensitive individuals than in their obese and insulin-resistant counterparts [139]