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Of relevance to traumatically induced SCI, motor neurons are also more vulnerable to proteasome inhibitor induced neurotoxicity, which includes apoptotic nuclear changes and mitochondrial dysfunction (Kikuchi et al., On the other hand, the drug bortezomib, a 26S proteasome inhibitor currently used in treatment of multiple myeloma, was found to be effective in reducing brain ischemia size in clinical studies (Shah and Di Napoli, 2007) by increasing ubiquitin expression in the infarct

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