isotopically labeled glutathione glutamate Detection of Reactive Metabolites Using Isotope-Labeled Trapping and Simultaneous Neutral Loss and Precursor Ion Scanning with Ultra-High-Pressure Liquid Chromatography Triple Quadruple Mass Spectrometry Glutathione metabolic pathways. GCL, glutamate

765 In addition, caffeic acid, 766 -caryophyllene, 767 15, 16-dihydrotanshinone, 768 icariside II, 769 rehmannioside A, 770 kaempferol, 771 rhein, 772 loureirin C, 773 quercetin, 774 and kellerin 775 suppress ferroptosis induced by cerebral I/R injury by activating the Nrf2 signaling pathway, which further suggests that activating the Nrf2 signaling pathway may be a potential treatment for relieving cerebral I/R injury

P.YangY.SunC

doi: 10.1073/pnas.92.18.8171

Entry into the DTP state can be driven by selective expansion of pre-existing subpopulations or induced dynamically in response to therapeutic pressure, reflecting stochastic cell-state transitions