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Bigal ME, Tepper SJ
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doi: 10.1074/jbc.R111.283432 100 ChenS-jAllamJ-PDuanY-gHaidlG
Enzymic antioxidants are themselves regulated at a gene level by nuclear factor E2-related actor 2 (Nrf2), a transcription factor normally located in the cytosol under basal oxidative conditions, being tightly regulated by Kelch-like ECH-associated protein 1 (Keap1), a redox-sensitive ubiquitin ligase which tethers Nrf2 within the cytosolic compartment (134, 135)
