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The response of plant defense system to stress varies with the times, duration of contact and stress severity, type of organ or tissue and developmental stage 10,11

While most of the current studies have been conducted in animal models, the results are impressive

However, overdose remains a leading cause of acute liver failure, primarily characterized by centrilobular (zone 3) hepatic necrosis, oxidative stress, mitochondrial dysfunction, and sterile inflammation

Emphasis will be placed on newer diagnostic strategies and the role of various therapeutic options, including treatment with selective dopamine agonists, in various clinical settings