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Additional strategies are broadening ferroptosis-based therapies in PC
Recently, vinca alkaloids have demonstrated to exert their neurotoxicity via activation of spinal cord glia (i.e., astrocytes and microglia), offering an option for the treatment of CIPN through pharmacological antagonism of this phenomenon
10.1016/j.freeradbiomed.2012.05.040 Free Radic
While these can provide localized antioxidant support, they often struggle to penetrate deep enough into the dermis to influence pigment production at the cellular level
