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SCD patients have aberrant metabolic regulation of fumarate, glutamate, glycine, malate, and other metabolites involved in glycolysis, nucleotide catabolism, and glutathione metabolism 3,4,5,6

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doi: 10.3389/fneur.2024.1366372 Received 08 January 2024 Accepted 12 April 2024 Published 06 May 2024 Volume 15 - 2024 Edited by Levent Ertugrul Inan, Health Science University Ankara SUAM, Trkiye Reviewed by Francesco De Logu, University of Florence, Italy Fu-Chi Yang, Tri-Service General Hospital, Taiwan Updates Copyright 2024 Chen, Yang, Tsai, Yang, Hsu, Chang and Yang

107 Several molecules were synthesized by substitution of the C4 position with either -keto, -olefin, -methyl, or -cyclopropyl functional groups, and the C2 position was single or double substituted with -chloro, -fluoro, -hydroxy, -methyl, or trifluoromethyl groups