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PMID: 36200910
Maenner MJ, Shaw KA, Bakian AV, Bilder DA, Durkin MS, Esler A, et al
This results in a failure to respond to PDE5 inhibitors for as long as 24 to 36 months or a need for long-term use of intracavernous injection therapy
In addition, the enhancement of FAO can be mediated by G protein-coupled bile acid receptor TGR5 agonists and accompanied by an increase in mitochondrial superoxide dismutase 2 (SOD2) activity, which reduces oxidative stress and lipid accumulation in the podocytes thereby attenuating the DKD injury [70]
