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In summary, while the lipidpodocyte axis provides a useful conceptual framework, substantial gaps remain in MN-specific mechanistic evidence, podocyte-resolved lipidomics, biomarker validation, and causal inference

Moreover, HEK-293 cells showed increased extracellular formate and hypoxanthine levels, reflecting mitochondrial dysfunction and disruptions in purine metabolism caused by oxidative stress (Oizel et al., 2020)

PMC 11594997

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