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2007 Jun;13(6):688-94

Mecanismos de Ao Estimula sntese de colgeno e elastina Aumenta sntese de glicosaminoglicano Modula enzimas chaves dependentes de cobre Estimula fibroblastos drmicos Estimula proteoglicanos da matriz (decorina) Ao antiinflamatria e antioxidante Modula mais de 4.000 genes regenerativos Estimula angiognese Promove a proliferao

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2 Methods 2.1 Search Strategy According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [12], the PubMed/MEDLINE and Scopus databases were reviewed independently by both authors (E.D.B