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However, these models are predominantly developed based on the prediction of molecular physiochemical properties, which is not designated to BBBP specific task and may not fully capture the specific molecular features associated with BBB penetration
doi: 10.1002/hep.20973
DLin-MC3-DMA was integral to the development of the first FDA-approved siRNA drug, Onpattro, and has been proven effective for mRNA delivery in vivo
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