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Sci.USA 104 , 45714576 (2007)

Inflammation of the tendons in the shoulder is often caused by repetitive motions over time and can lead to pain and stiffness
In preclinical models of obesity, hypoxia-driven endothelial dysfunction promotes systemic insulin resistance through chronic inflammation 56,57 , excessive macrophage infiltration 58 , immune cell polarization toward a proinflammatory phenotype 59 , and ECM remodeling 60 , ultimately impairing adipocyte function and exacerbating metabolic dysregulation

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