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CDRs complementarity determining regions a humanised antibody only the complementarity determining regions (CDRs) which are responsible for antigen binding and specificity are animal derived and have an amino acid sequence corresponding to the animal antibody, and substantially all of the remaining portions of the molecule (except, in some cases, small portions of the framework regions within the variable region) are human derived and correspond in amino acid sequence to a human antibody

Wnt signaling inhibits osteoclast differentiation by activating canonical and noncanonical cAMP/PKA pathways

Interestingly, in addition to raised glucose serum levels in alloxan treated animals, an exaggerated appearance of gastric lesions was noted in control diabetic rats

G., Hilarius P