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The high number of animals used in environmental risk assessment has highlighted the need for novel approaches and development of in vitro assays

Hamilton-Reeves, Assistant Professor, University of Kansas Medical Center, School of Health Professions, Department of Dietetics & Nutrition, 3901 Rainbow Boulevard, Mail Stop 4019, 4093 DELP, Kansas City, KS 66160, Phone: 913-588-7650, Fax: 913-588-8946

Included in protocols where oxidative stress management is the primary goal, with the evidence limitation disclosed to patients

By blocking PDH activity, pyruvate is prevented from entering the TCA cycle, reducing mitochondrial oxygen consumption and favoring glycolysis (70)