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Precursors entering the gut are absorbed by the upper gastrointestinal tract during oral administration and are unavailable to the microbes in the large intestine
The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration
The study concept is based on an academic patent (patent number WO2015173258 A1)
