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This ancient clade most likely originated from an evolutionary distant algal 2OGD that gradually diverged into a functioning ACO during seed plant evolution

Berberine (from Berberis species) is an isoquinoline alkaloid with broad neuroprotective mechanisms (antioxidant, antiapoptotic, antiinflammatory) [43]

doi: 10.1111/ans.19155 87 ThatipamalaPNoelJEOrloffL
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