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A larger study by the Hanson group employed machine learning to distinguish ME/CFS patients from healthy controls with 79.1% accuracy (AUROC value 0.891) using only seven proteins (Giloteaux et al., 2023)

In this example and in type 1 diabetes, it has been discussed whether the normalization of glucose metabolism following rhIGF-I therapy is most importantly associated with insulin-like effects of IGF-I on glucose uptake in muscle or suppression of GH hypersecretion
