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Description
The majority of trials have adopted intravenous delivery for stem cell administration as this is much less invasive than intracranial injections [219]
& Nadimi, M
Settlement in supportive niches enables them to survive and retain their stem-like tumor-initiating capacity
In particular, the harmonization led by the International Council for Harmonisation (ICH) through the E19 guideline , in alignment with foundational principles in ICH E3 clinical study reports , marks a major evolution in how sponsors can optimize safety data collection without compromising regulatory rigor or patient welfare
