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Things fried in a lot of oils or meats that have a lot of fat are bad for both blood pressure and cholesterol

[PubMed: 16411879] (Letter documenting the rise in abuse of kava among Aboriginal people in Australia and call for further regulatory actions)

Seemingly, KYNA (and its 7-chloro derivative) can also be effluxed by MRCP4 (ABCC4) as well as by SLC22A6/8 [242,244], as each of these transporters is inhibited by probenecid, whose presence led to an 885-fold increase in the concentration of 7-Cl-KYNA in the prefrontal cortex of rats [242] (see also [240,245,246,247,248,249,250])

OS-induced mitochondrial damage in pyramidal neurons is considered a hallmark of mitophagy dysfunction in neurodegenerative diseases (Talebi et al., 2022)