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Nrf2 and Oxidative stress: A general overview of mechanisms and implications in human disease

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Through their collective capacity for modulating the immune system and lessening inflammation, these therapies hold the potential to be utilized as adjunctive therapies in SLE management

First, the sgRNAs [ Mpst upstream (target sequence: 5GGAGAGACAAGCCTGCATTC AGG 3) at intron 1 and Mpst downstream (target sequence: 5GTGGGTGGCGGAGGCTCTGA AGG 3) at exon 2, where the underlined bases indicate the PAM sequences] were synthesized in vitro (T7 gRNA Smart Nuclease Synthesis Kit, System Biosciences, Mountain View, CA, USA) following the manufacturer's instructions
