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Nutrition and metabolic insights , 9 , 2530

Materials and Methods Ethics statement The animal experimental procedures were approved by the CEBEA (Comit dthique et du bien-tre animal) of the IBMM (Institut de Biologie et de Mdecine Molculaires) -ULB and conformed to the European guidelines on the ethical care and use of animals

In a PRMT5-deficient environment, the TIP60 complex cannot function to promote HR and consequently error-prone NHEJ is favoured a potential explanation for upregulation of p53 seen previously (65)

Research has shown that metabolic reprogramming in tumors is involved in the activation and differentiation of hepatic stellate cells (HSCs), such as acidification of the microenvironment inducing HSC activation and differentiation into myofibroblasts in a P-Erk1/2-dependent manner ( Compared with quiescent HSC (qHSC), activated HSC (aHSC) exhibit higher rates of glucose utilization, transport capacity, and glycolytic activity ( Rapid proliferation of liver cancer cells can deplete nutrients in the microenvironment, leading to sustained nutrient deprivation and decreased oxygen levels