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Description
Within 48 hours after injection of 100 or 1000 mcg of vitamin B12, 50 to 98% of the injected dose may appear in the urine

Vitamin B12 Deficiency

Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

This is attributed to the heightened levels of NNMT potentially rendering NAM irretrievable, thereby constraining NAD + -dependent processes (Trammell and Brenner, 2015)