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Central & Peripheral Anti-Obesity Targets (PMC) AOD-9604 RCT summary and mechanistic overview PubMed Metabolic studies of AOD-9604 in obese rodents (oral dosing, fat oxidation) Related research, protocols, and guides Explore the available research context, protocol variants or comparisons, and practical guides
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In brief, when TrkB and p75 NTR co-express in the same cells, p75 NTR enhances neurotrophin binding to TrkB, augmenting both ligand affinity and selectivity, hence, reinforcing the TrkB-mediated trophic response via up-regulation of PI3K/Akt and/or IRAK/NF-B signaling 3
