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doi: 10.1021/acs.molpharmaceut.0c00495 [DOI] [PubMed] [Google Scholar] 29.Fukuda M, Kanazawa T, Iioka S, et al

However, when glutamine metabolism is targeted with a single treatment, tumor cells will activate other signaling pathways or strengthen glutamine metabolism reprogramming to meet their energy demand, resulting in different degrees of drug resistance in tumor cells, thus restricting targeted glutamine metabolism therapy

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In RA patients ( N = 17), iVNS was shown to inhibit peripheral cytokine production and significantly reduce TNF, IL6, and IL1 levels, with associated decreases in swollen joint counts and disease activity scores