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In the general population, metallome profiling serves as a foundational tool for the execution of biomonitoring strategies (Figure 1B)

Key results, proposed mechanisms, and limitations across relevant animal, observational, and clinical studies are summarized in Table 3

Psychoneuroendocrinology 134:105448 Nishino S, Ueno R, Ohishi K, Sakai T, Hayaishi O (1989) Salivary prostaglandin concentrations: possible state indicators for major depression

Repeat treatment may be needed, so its usually reserved for special cases with small prostates
