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In a mouse model of Huntington's disease, GPx6 overexpression in the frontal cerebral cortex improved motor defects in aged animals (Shema et al

Cellular Redox Network and Redox Stress Redox network in mammalian cells The cellular redox niche is balanced by pro-oxidants and antioxidants

Due to the properties of GSH (namely its size and net negative charge), GSH transport generally requires some form of carrier to cross the plasma membrane, or the membranes of organelles to reach its many targets

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