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Evidence From In Vitro Human Adipose and Skin Models and Pilot Clinical Trial

We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29

Although dual and triagonist medications have so far exhibited side effects comparable to those of GLP- 1 receptor monoagonists in human trials, these preclinical findings imply that GIP receptor agonism may be the secret to obtaining the weight loss advantages of incretin agonism with less severe side effects

Physiological Functions Beyond its original sleep-promoting properties, DSIP exhibits a remarkably broad range of biological activities: Neuromodulatory Effects : DSIP influences various neurotransmitter systems, including GABA, serotonin, and dopamine pathways