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In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression

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These limitations underscore the existing knowledge gaps and emphasize the need for continued in-depth research into 4-HNEmediated mechanisms

ITGB8 encodes a beta subunit of integrin (integrin beta 8) (He et al., 2018) and is the target gene of miR-761
