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HDAC9 mediates the deacetylation and ubiquitination of the transcription factor Sp1 through its histone deacetylase activity modification, leading to Sp1 degradation, which inhibits the transcriptional expression of GPx4, a key factor in resistance to ferroptosis, and ultimately drives neuronal ferroptosis in models of cerebral ischemia

The indispensable role of the C terminal domain in preventing fibrillation has been demonstrated by an engineered -synuclein with truncated C terminus which not only displayed accelerated fibrillation kinetics but also promoted the phase separation of WT -synuclein (Huang et al., 2022)

Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the molecular weight of drugs

Quercetin, one of the most extensively studied honey polyphenols, has shown the ability to inhibit various kinases involved in cancer cell signaling, including membrane tyrosine kinases and protein kinase C