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In our experiments, the truncation of the LRRK2 protein through CRISPR/Cas9 gene editing did not produce any detectable detrimental results and provides an alternative method for decreasing kinase activity in a more targeted manner
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
n = 6 mice for each genotype
Here, catecholamines facilitate widespread central sensitization and dysregulate descending inhibitory pathways, contributing to chronic pain in the absence of clear tissue or neural damage
