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The modifications are real and chemically meaningful, but the leap from this version is more chemically stable to you need 1/50th the dose involves more assumption than measurement

Turley and Dietschy 1978)

Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, panic Symptoms, and stress biomarkers: A phase I randomized trial in healthy males
