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DN is pathologically characterized by mesangial matrix thickening, progressive destruction of glomerular and tubulointerstitial, and loss of functioning glomeruli, ultimately leading to chronic renal failure [138, 139]

Although m6A modification does not directly modify proteins, it indirectly regulates protein expression by modulating RNA, particularly the stability, translation efficiency, and splicing of mRNAs, thereby affecting the levels and activity of lipid-metabolizing enzymes
