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Gen Pharmacology: Vascular Syst 27:713722 Howard SC, McCormick J, Pui C-H, Buddington RK, Harvey RD (2016) Preventing and managing toxicities of high-dose methotrexate
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Muscle overuse releases a higher level of ROS and alters inflammatory cascades which ultimately leads to DNA damage and reduces DNA repair protein expressions
However, certain limitations in the studies call for careful interpretation
