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In this case, the B12 shots have started to heal the damaged neurons myelin sheath, but the neural network in which the healed neuron is in, is in a super sensitive state (with extra receptors), so the patient may feel pain or other unpleasant sensations

Lack of Vitamin B-12 Leads to Weight Gain Somehow According to observational studies, people suffering from obesity or are overweight tend to have lower vitamin B-12 levels in their systems